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Synergies are extra buffs that your team obtains when you combine certain Heroes on your team. You can create multiple synergies within a team. Having multiple of the exact synergy will not stack the buff and Friends do not effect synergy combinations.
Note - You cannot use different rarities to create a synergy, all cards need to be the same rarity

Check out each Common, Uncommon, Rare and Epic to view all synergies for that specific rarity.